| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754682 | Journal of Inorganic Biochemistry | 2016 | 9 Pages |
Abstract
Triapine has been investigated as anticancer drug in multiple clinical phase I/II trials, however it was rather ineffective against solid tumors. The reasons are currently widely unknown. Therefore, we investigated Triapine and its biologically active species Fe-Triapine in cell extracts and body fluids of mice.167
Keywords
Dp44mTFLDdNTPPBSFCSPBMCLOQ3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideDMSOMTTTriapinefluorescence detectionEPRElectron paramagnetic resonanceDrug developmentThiosemicarbazonesLOD یا Limit of detectiondeoxynucleoside triphosphateIn vivoDimethyl sulfoxideRibonucleotide reductasefetal calf serumperipheral blood mononuclear cellsMass spectrometryICP-MSinductively coupled plasma mass spectrometryPharmacokineticsPhosphate buffered salinelimit of quantificationlimit of detectionEIChigh performance liquid chromatographyHPLCextracted ion chromatogram
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Karla Pelivan, Walter Miklos, Sushilla van Schoonhoven, Gunda Koellensperger, Lars Gille, Walter Berger, Petra Heffeter, Christian R. Kowol, Bernhard K. Keppler,