| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754735 | Journal of Inorganic Biochemistry | 2016 | 7 Pages |
Abstract
The Ru(II) arene anticancer complex, after irradiation by UVA and visible light, induces efficient cleavage of double-helical DNA also in the cancer cells. Concomitantly the irradiation markedly enhances toxicity of the Ru(II) complex in cancer cells. The mechanism of DNA photocleavage involves a direct attack of ruthenated guanine residues.130
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Viktor Brabec, Jitka Pracharova, Jana Stepankova, Peter J. Sadler, Jana Kasparkova,