| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754793 | Journal of Inorganic Biochemistry | 2016 | 22 Pages |
Abstract
Studies on the biodistribution and plasma protein binding of the anticancer agent Na trans-[RuCl4(1H-indazole)2] (NKP-1339) in mice show that, in analogy to KP1019, a large portion of the Ru is attached to albumin and albumin aggregates. The highest concentration of Ru was found in colon, lung, liver, kidney and thymus.240
Keywords
NCICZEBGETOFMSAHSAICPKP1019TransferrinESINAMI-Ahuman serum albuminmouse serum albuminCapillary zone electrophoresisbackground electrolyteIndazoleCancer researchEPRElectron paramagnetic resonanceTissue distributiontime of flightMass spectrometryinductively coupled plasma mass spectrometrymatrix assisted laser desorption/ionizationMALDIRuthenium(III) complexesinductively coupled plasmaliquid chromatographyelectrospray ionization
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
![Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action](/preview/png/7754793.png "First Page Preview: Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action")
Authors
Anna K. Bytzek, Gunda Koellensperger, Bernhard K. Keppler, Christian G. Hartinger,