| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754801 | Journal of Inorganic Biochemistry | 2016 | 45 Pages |
Abstract
Tremendous differences in rate of reduction, cellular accumulation and cytotoxicity were found between biscarboxylatoplatinum(IV) complexes and their tri- and tetracarboxylato analogs. In particular, the mode of cellular uptake differs substantially depending on the equatorial ligand sets.66
Keywords
RPMIPBSGSHFBSsupercoiledTBEnuclear magnetic resonance3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideDNAMTTROSAscorbic aciddeoxyribonucleic acidstandard deviationCellular accumulationTris-Borate-EDTATris-EDTANMRminimum essential mediumopen circularRedox behaviorfetal bovine serumCytotoxicityinductively coupled plasma mass spectrometryICP-MSDulbecco's phosphate-buffered salineLipophilicityMEMRoswell Park Memorial Institute mediumPlatinum(IV) complexesGlutathioneReactive oxygen species
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Simone Göschl, Hristo P. Varbanov, Sarah Theiner, Michael A. Jakupec, Markus Galanski, Bernhard K. Keppler,