| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754859 | Journal of Inorganic Biochemistry | 2015 | 10 Pages |
Abstract
Quinoline-2-carboxaldehyde thiosemicarbazone derivatives and their copper(II) and nickel(II) complexes were tested for their antiproliferative properties on cell line U937. Copper(II) derivatives inhibit proliferation and topoisomerase IIa in vitro. Computational methods suggest that the positive charge formed by dissociation of the copper complexes may play a key role in their activity.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Franco Bisceglie, Anastasia Musiari, Silvana Pinelli, Rossella Alinovi, Ilaria Menozzi, Eugenia Polverini, Pieralberto Tarasconi, Matteo Tavone, Giorgio Pelosi,