Structure-specific adipogenic capacity of novel, well-defined ternary Zn(II)-Schiff base materials. Biomolecular correlations in zinc-induced differentiation of 3T3-L1 pre-adipocytes to adipocytes

Appropriately configured and well-defined ternary zinc-organic (Schiff-base) ligand materials induce 3T3-L1 pre-adipocyte differentiation to mature adipocytes. Structure specificity of the newly synthesized “zincoforms” a) correlates with specific insulin-like bioactivity validated by targeted adipogenic biomarkers, and b) sets the stage for the development of effective “zincodrugs” in Diabetes Mellitus II.