| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754944 | Journal of Inorganic Biochemistry | 2015 | 7 Pages |
Abstract
The measured adsorption of MPL® to l-tyrosine in MATA-MPL allergy immunotherapy formulations, which has been shown to be disrupted by the addition of naphthalene a stronger aromatic centre, could depend significantly on C-Hâ¯Ï interactions between upward facing C-H's on the 2-deoxy-2-aminoglucose of MPL® and the aromatic ring on l-tyrosine.
Keywords
TLR4PSIRCFGMPMCTDPBSEMAPLCIgE%RSDTh2allergoidRPMQAUC–H⋯π interactionsIgGWFImatABSAflame ionisation detectorbovine serum albuminEuropean Medicines agencystandard deviationImmunoglobulin Eimmunoglobulin GEnzyme-linked immunosorbent assayELISAGood Manufacturing PracticeFIDWorld Health Organisationrevolutions per minuteEuropean PharmacopeiaDulbecco's phosphate buffered salineMonophosphoryl lipid ALTDLimitedrelative centrifugal forceUnited Kingdompounds per square inchGas chromatographyWHO
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
A.J. Bell, M.D. Heath, S.J. Hewings, M.A. Skinner,