| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754983 | Journal of Inorganic Biochemistry | 2015 | 4 Pages |
Abstract
The 5xFAD transgenic Alzheimer's disease (AD) mouse-model exhibits progressive amyloidogenesis; aluminum-fed 5xFAD mice display accelerated amyloid deposition. 5xFAD animals also display up-regulation of the inflammatory-biomarkers COX-2 and CRP; for the first time we demonstrate the propagation of AD-type change into the retina; this may have relevance for 'pathological spreading' mechanisms.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
AI Pogue, P Dua, JM Hill, WJ Lukiw,