Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7754986 | Journal of Inorganic Biochemistry | 2015 | 12 Pages |
Abstract
DNA adducts of monofunctional Pt agents with bulky carrier ligands sterically clash with nucleobases, causing structural distortions responsible for anticancer activity. The ratio of syn to anti rotamers is higher for Pt(N-(6-methyl-2-picolyl)-N-(2-picolyl)amine)(N9-guanine derivative) adducts than for comparable adducts with either more or less bulky ligands, providing insight into steric interactions.94
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Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Chase Andrepont, Patricia A. Marzilli, Svetlana Pakhomova, Luigi G. Marzilli,