Article ID Journal Published Year Pages File Type
7754986 Journal of Inorganic Biochemistry 2015 12 Pages PDF
Abstract
DNA adducts of monofunctional Pt agents with bulky carrier ligands sterically clash with nucleobases, causing structural distortions responsible for anticancer activity. The ratio of syn to anti rotamers is higher for Pt(N-(6-methyl-2-picolyl)-N-(2-picolyl)amine)(N9-guanine derivative) adducts than for comparable adducts with either more or less bulky ligands, providing insight into steric interactions.94
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Physical Sciences and Engineering Chemistry Inorganic Chemistry
Preview
Guanine nucleobase adducts formed by a monofunctional complex: [Pt(N-(6-methyl-2-picolyl)-N-(2-picolyl)amine)Cl]Cl
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