| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754999 | Journal of Inorganic Biochemistry | 2015 | 8 Pages |
Abstract
Cisplatin is a potent anticancer drug, yet its efficacy is limited by resistance. Hybrid QM/MM and metadynamics simulations combined with experiments provided insights on the structure and recognition processes of the drug with its cellular targets. These studies might contribute to design new cisplatin derivatives able to circumvent resistance.250
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Vania Calandrini, Giulia Rossetti, Fabio Arnesano, Giovanni Natile, Paolo Carloni,