The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex

The reactivity of platinated methionine-rich motif (Mets7) of CTR1 is dependent upon the type of precursor complex. The cisplatin/Mets7 adduct reacts readily with both cysteine and histidine. In contrast, the oxaliplatin/Mets7 adduct reacts with cysteine but not with histidine, whereas the cDPCP/Mets7 adduct reacts with histidine but not with cysteine.136