| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7755011 | Journal of Inorganic Biochemistry | 2015 | 6 Pages |
Abstract
Cisplatin is a chemotherapy drug. We report that cisplatin inhibits in dose-dependent fashion the enzymatic proteasome activities. Cisplatin administration to neuroblastoma cells also brings about a loss of proteasome activity followed by proteasome de novo synthesis. Finally, the co-administration of lactacystin (specific proteasome inhibitor) and cisplatin enhances cisplatin cytotoxicity.153
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
G.R. Tundo, D. Sbardella, C. Ciaccio, S. De Pascali, V. Campanella, P. Cozza, U. Tarantino, M. Coletta, F.P. Fanizzi, S. Marini,