| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7755160 | Journal of Inorganic Biochemistry | 2014 | 8 Pages |
Abstract
Binding affinities for exogenous ligands were regulated by a disulfide bond in Cgb. The formation of the disulfide bond caused alteration of space of cavity, and the variation was also suggested by computational simulations. Remarkably, a structure with a disulfide bond showed 2.5 to 100-fold higher affinities for exogenous ligands.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Hirofumi Tsujino, Taku Yamashita, Azusa Nose, Kaori Kukino, Hitomi Sawai, Yoshitsugu Shiro, Tadayuki Uno,