| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7755320 | Journal of Inorganic Biochemistry | 2013 | 9 Pages |
Abstract
Complexation of chrysin, apigenin, and genistein to Cu(II) trebles their cytotoxicity against cancer cells. While the apigenin complex destabilizes their F-actin cytoskeleton and stimulates the expression of matrix metalloproteinases, the genistein complex supports cell-cell adhesion by actin remodeling, cadherin-catenin complex formation, and a reduced expression and secretion of MMPs.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Cornelia Spoerlein, Katharina Mahal, Holger Schmidt, Rainer Schobert,