| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7755335 | Journal of Inorganic Biochemistry | 2013 | 15 Pages |
Abstract
A new set of bifunctional MMP inhibitors bearing a benzothiazole moiety reveals high inhibitory activity (subnamomolar to high micromolar) against MMP2 and also high anti-proliferative activity of A2780 ovarian cancer cell line. These properties combined with the high resistance to hydrolysis suggest that these compounds may be considered for a new generation of anti-cancer MMPIs.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Sérgio M. Marques, Claudia C. Abate, SÃlvia Chaves, Fernanda Marques, Isabel Santos, Elisa Nuti, Armando Rossello, M. Amélia Santos,