Development of metal-chelating inhibitors for the Class II fructose 1,6-bisphosphate (FBP) aldolase

Derivatives of the metal-chelator dipicolinic acid were synthesized, and tested for their capacity to inhibit microbial Class II FBP aldolase, a potential new drug target. The compounds were docked and minimized into the active site of the M. tuberculosis FBP aldolase (PDB ID 3EKZ) to guide future rational design of inhibitors.