| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7756991 | Journal of Organometallic Chemistry | 2015 | 10 Pages |
Abstract
The chloride salt of the cation [(p-MeC6H4Pri)2Ru2(SC6H4-p-But)3]+, called diruthenium-1, shows high anticancer activity in vitro and in vivo. With IC50 values in the nanomolar range, this compound prolongs significantly the survival of tumour-bearing mice. Diruthenium-1 activates p53, decreases the intracellular concentration of glutathione and inhibits the mitochondrial respiration.85
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
![[(p-MeC6H4Pri)2Ru2(SC6H4-p-But)3]Cl (diruthenium-1), a dinuclear arene ruthenium compound with very high anticancer activity: An in vitro and in vivo study](/preview/png/7756991.png "First Page Preview: [(p-MeC6H4Pri)2Ru2(SC6H4-p-But)3]Cl (diruthenium-1), a dinuclear arene ruthenium compound with very high anticancer activity: An in vitro and in vivo study")
Authors
Pavel TomÅ¡Ãk, Darina Muthná, Martina ÅezáÄová, Stanislav MiÄuda, Jana Ämielová, MiloÅ¡ Hroch, René Endlicher, Zuzana Äervinková, Emil Rudolf, Stephan Hann, David StÃbal, Bruno Therrien, Georg Süss-Fink,