Article ID Journal Published Year Pages File Type
7757219 Journal of Organometallic Chemistry 2014 13 Pages PDF
Abstract
Several new trimetallic Ru(II)- and Os(II)-arene complexes based on tris-2-(salicylaldimine ethyl)amine and tris-2-(2-pyridylimine ethyl)amine scaffolds were synthesized and characterized. These complexes display moderate to high cytotoxicity against human osteosarcoma (MG63) and ovarian cisplatin resistant (A2780cisR) cancer cells. Furthermore, the systems serve as inhibitors and/or poisons to DNA topoisomerase I (Topo I).
Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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