Benzo[b]furan derivatives induces apoptosis by targeting the PI3K/Akt/mTOR signaling pathway in human breast cancer cells

Benzo[b]furan derivatives (26 and 36) showed significant antiproliferative activity against human breast cancer cell line, MCF-7. These benzo[b]furan derivatives were investigated for their mechanism and apoptotic pathway against human breast cancer cell line, MCF-7. Western blot analysis suggested that these compounds inhibit the PI3K/Akt/mTOR signaling pathway and induced mitochondrial mediated apoptosis in human breast cancer cell line, MCF-7.