| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7772197 | Bioorganic Chemistry | 2012 | 12 Pages |
Abstract
⺠Thirty-two conformationally constrained phenanthrolines and dihydrothienoquinolines were synthesized. ⺠Prepared compounds were evaluated for topo I and II inhibitors, and cytotoxicity. ⺠Compounds 33 and 35 displayed significant topo I inhibitory activity. ⺠Compounds 10, 14, and 18 exhibited strong cytotoxicity. ⺠SAR exhibited that [2,2â²;6â²,2â³]-terpyridine skeleton is important for cytotoxicity.
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![2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study](/preview/png/7772197.png "First Page Preview: 2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study")
Authors
Pritam Thapa, Radha Karki, Han Young Yoo, Pil-Hoon Park, Eunyoung Lee, Kyung-Hwa Jeon, Younghwa Na, Won-Jea Cho, Youngjoo Kwon, Eung-Seok Lee,