Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7781408 | Carbohydrate Polymers | 2018 | 25 Pages |
Abstract
An efficient and mild procedure was developed for the preparation of three chitosan-supported ureas containing electron-withdrawing groups. These catalysts were characterized and employed as organocatalysts in different transformations, including the enantioselective cyanosilylation of α-ketoesters and aldehydes, the asymmetric addition of formaldehyde tert-butyl hydrazone to prochiral α-ketoesters and a Friedel-Crafts reaction. Several parameters that can affect the activity and selectivity of the reactions were analysed. The supported catalysts can be reused for more than 10 cycles with only a small loss in their properties. Finally, theoretical DFT calculations were carried out to interpret the results of the catalysed reactions.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gonzalo de Gonzalo, Antonio Franconetti, Rosario Fernández, José M. Lassaletta, Francisca Cabrera-Escribano,