Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7781409 | Carbohydrate Polymers | 2018 | 9 Pages |
Abstract
A promising approach for improving the interfacial bonding of a three-dimensionally (3D) printed multilayered structure has been investigated by taking advantage of the electrostatic interactions between two hydrogels with oppositely charges. Here, two hydrogels namely gelatin and κ-carrageenan, which are the cationic and anionic hydrogels respectively, are used. It is found that the interfacial bonding strength between these two oppositely charged hydrogels is significantly higher than that of a bilayered gelatin or a bilayered κ-carrageenan. The bioprinted multilayered κ-carrageenan-gelatin hydrogel construct demonstrates a very good biocompatibility and a good structure integrity at 37â¯Â°C. Our strategy also overcomes the limitation of using gelatin for bio-fabrication at 37â¯Â°C, without further post crosslinking.
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Authors
Huijun Li, Yu Jun Tan, Lin Li,