Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7781626 | Carbohydrate Polymers | 2018 | 25 Pages |
Abstract
This work firstly aimed to synthesize mono- and di- sulfonic derivatives of chitosan by reductive amination reaction using respectively 2-formyl benzene sulfonic acid and 2,4 formyl benzene sulfonic acid sodium salts. The influence of the reactants molar ratio (R), aryl - substituted amino groups versus chitosan free amino groups, on the degree of substitution (DS) of both sulfonated chitosans was assessed by 1H NMR, elemental analysis, coupled conductometry-potentiometry analysis and UV spectrometry and FTIR. The influence of pH on sulfonated chitosans' properties in solution were investigated by solubility and zeta potential (ZP) studies, size exclusion chromatography equipped with MALLS detection (SEC-MALLS) and Taylor dispersion analysis (TDA). The polyampholytic character of both series was evidenced and strongly modified the solutions properties compared to chitosan. Then, the anticoagulant properties of mono- and di- sulfonic polymers were investigated by the measurement of the activated partial thromboplastin time (aPTT), Prothrombin-time (PT) and anti-(factor Xa).
Related Topics
Physical Sciences and Engineering
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Authors
Safa Ouerghemmi, Syrine Dimassi, Nicolas Tabary, Laurent Leclercq, Stéphanie Degoutin, Feng Chai, Christel Pierlot, Frédéric Cazaux, Alexandre Ung, Jean-Noel Staelens, Nicolas Blanchemain, Bernard Martel,