Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7782255 | Carbohydrate Polymers | 2018 | 30 Pages |
Abstract
Exploring the long-term filler for minimally invasive plastic surgery has been widely concerned. In the present study, a series of injectable paste composed of hydroxyapatite (HAp) spherical particles and cross-linked sodium hyaluronate (cHA) solution were prepared. The physicochemical properties of cHA as a carrier of high content HAp microspheres (>50%) and as-obtained injectable HAp/cHA paste were studied. The cross-linking degree (DC), viscosity and molecular weight (Mw and Mn) of cHA increased with the increasing of the cross-linker dosage from 7.5 to 17.5â¯wt% under the certain conditions. HAp/cHA pastes were fabricated by homogeneously blending different sizes of HAp microspheres with cHA solution. The stability, rheological performance and push-out force of the pastes were studied, and the influence factors were discussed. The results indicated that moderate crosslinked cHA with 60% middle size HAp (HAp-M60/cHA-15.0) had appropriate comprehensive property. Finally, the in vitro cell culture approved the paste had no cytotoxicity. Although the biological performance of the pastes still need to be investigated, this preliminary study demonstrates that it is possible to carry high content HAp in cHA, expecting the better volumetric maintenance after long term implantation.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yan Liu, Yonghao Wu, Hai Lin, Yumei Xiao, Xiangdong Zhu, Kai Zhang, Yujiang Fan, Xingdong Zhang,