Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7782723 | Carbohydrate Polymers | 2018 | 33 Pages |
Abstract
The fucose-containing sulfated polysaccharides (syn. fucoidans) from brown algae exhibit a wide range of bioactivities and are therefore considered promising candidates for health-supporting and medical applications. During the past three decades, research on isolation, molecular characterization, and screening of in vitro and in vivo pharmacological activities has significantly increased. Until now, however, fucoidans are only used as ingredients in cosmetics and food supplements, especially due to the proclaimed antioxidant activities of fucoidan. One obstacle to medical applications is the usually high molecular mass of native fucoidans, as it is associated with unfavorable biopharmaceutical properties and possibly undesired effects. Therefore, it seems reasonable to develop fucoidan derivatives with reduced size. So far, in this study, fucoidan from Fucus vesiculosus was gradually degraded from Mw 38.2 down to 4.9â¯kDa without concomitant desulfation. Compared to hydrothermal treatment, the degradation with H2O2 showed to be more efficient and additionally eliminated the antioxidant and antiproliferative activities of the genuine fucoidan. This confirmed our previous hypothesis that rather co-extracted compounds like terpenoids and polyphenols than the fucoidan itself exhibit these effects.
Keywords
Algae polysaccharidesMLEVMALLSMHVDepolymerizationSECDPPHchondroitin sulfate C2,2-diphenyl-1-picrylhydrazyl radicalHydrogen peroxideDegradationHydrodynamic volumedegree of sulfationHydrothermal treatmentFTIRFourier transform infrared spectroscopyFucoidanH2O2multi-angle laser light scatteringSize exclusion chromatography
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eric Lahrsen, Inga Liewert, Susanne Alban,