Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7783986 | Carbohydrate Polymers | 2018 | 28 Pages |
Abstract
Photocrosslinkable hydrogels composed of natural materials exhibit great application potential in tissue engineering scaffolds. However, weak formation and poor mechanical property can usually be a limitation. Herein, the photo-clickable thiol-ene hydrogels based chitosan were synthesized using photopolymerization of maleic chitosan (MCS) and thiol-terminated poly (vinyl alcohol) (TPVA) in the presence of a biocompatible photoinitiator. Rheological property and absorbing behavior of the MCS/TPVA hydrogels could be tailored by varying the amount of TPVA in the feed. There was strong intermolecular hydrogen bonding between the molecules of MCS and TPVA. Notably, the MCS/TPVA hydrogel (MT-3) exhibited rapid gelation behavior (<120â¯s), improved stiff (G'â¯=â¯â¼5500â¯Pa) and compressive strength (0.285â¯Â±â¯0.014â¯MPa), which were important for hydrogel scaffolds, especially for injectable hydrogel scaffolds. Photocrosslinked MCS/TPVA hydrogels was cytocompatible and could promote the L929 cells attachment and proliferation, showing their potential as tissue engineering scaffolds.
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Authors
Yingshan Zhou, Shuyan Zhao, Can Zhang, Kaili Liang, Jun Li, Hongjun Yang, Shaojin Gu, Zikui Bai, Dezhan Ye, Weilin Xu,