Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7784042 | Carbohydrate Polymers | 2018 | 39 Pages |
Abstract
The objective of this study was to analyse the structure of CPP-2, and to observe the pharmacological effects of CPP-2 on lipid metabolism and oxidative stress. CPP-2, eluted as two main fractions comprised of two polysaccharides with Mw of 307 and 3.7Â kDa, was mainly consisted of rhamnose, mannose, glucose and galactose in a molar ratio of 1.00:0.78:3.22:0.45. The results showed that treatment with CPP-2 could improve blood lipid levels (TC, TG, HDL-C and LDL-C), liver lipid levels (TC and TG) and antioxidant status (SOD, T-AOC, GSH-PX, MDA and LPO). In addition, the histopathological observations of mice livers and the GPT activities indicated that CPP-2 could attenuate liver cell injury. The present findings demonstrated that CPP-2 might be effective in lowering lipid and protecting against HFE-induced hyperlipidemia and non-alcoholic fatty liver.
Keywords
MDAT-AOCHFEHDL-CLDL-CLPOGPTBCAGSH-PxHepatoprotective effectbicinchoninic acidTriacylglycerolsSODSuperoxide dismutaseAntioxidant activityAntihyperlipidemic activityhigh-density lipoprotein cholesterolmalondialdehydeweight-average molecular weightLipid peroxidePolysaccharidetotal cholesterolLow-density lipoprotein cholesterolCyclocarya paliurusglutathione peroxidaseglutamate pyruvate transaminase
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhanwei Yang, Jin Wang, Jingen Li, Lei Xiong, Hui Chen, Xin Liu, Ning Wang, Kehui Ouyang, Wenjun Wang,