Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7784519 | Carbohydrate Polymers | 2018 | 28 Pages |
Abstract
This study was to evaluate the protective effects of a dietary fiber, konjac glucomannan (KGM) from the plant tuber of Amorphohallus konjac on Bifidobacteria against antibiotic damage. KGM (â¼8.8Â ÃÂ 108Â Da) was partially degraded with high-intensity ultrasound to KGM-US (â¼1.8Â ÃÂ 106Â Da) and then hydrolyzed with trifluoroacetic acid (TFA) to KGM-AH (1369Â Da). KGM-US (at 5Â g/l) showed the most significant protective effect on most bifidobacterial strains against penicillin and streptomycin inhibition, increasing the minimal inhibitory and bactericidal concentration (MIC and MBC) dramatically, and KGM also showed significant effects on enhancing the MBC of enrofloxacin, penicillin, tetracycline and streptomycin. In addition, the adsorbance ability and biofilm formation effects of KGM and degraded KGM products may be partially responsible for the protective effects. The results suggested that natural KGM and ultrasound treated KGM have protective effects for the human gut probiotic bacteria against the damage caused by specific antibiotics.
Related Topics
Physical Sciences and Engineering
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Authors
Yu-Heng Mao, Ang-Xin Song, Zhong-Ping Yao, Jian-Yong Wu,