Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7786644 | Carbohydrate Polymers | 2016 | 12 Pages |
Abstract
Nitrocellulose liquid bandage (L-Bandage) is extensively used in hard-to-cover cuts and wounds management, owing to its flexibility, softness, transparency, and conformability. However, evidence supporting their mechanisms of action as wound dressing is scanty. This study introduces a novel nano-porous L-Bandage, and provides results from a mouse full-thickness wound model investigating its mechanism of action on wound healing. Different characteristics, such as porosity, mechanical properties and water vapor transmission rate (WVTR) were determined. The L-Bandage formed film had a porous network structure with mean diameter of 18Â nm that could effectively prevent the bacterial invasion, and favorable properties of tensile strength, elongation, and WVTR. The L-Bandage treated wound exhibited accelerated healing, with reduced inflammations, enhanced wound re-epithelialization, contraction, granulation tissue formation, and rapid angiogenesis. Our data suggested that L-Bandage could serve as a promising wound dressing, because of its desirable properties for wound healing.
Related Topics
Physical Sciences and Engineering
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Authors
Xiaofeng Mu, Hao Yu, Caizhen Zhang, Xiufang Chen, Zhiyun Cheng, Ruyu Bai, Xunxun Wu, Qian Yu, Chunlin Wu, Yong Diao,