Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7787425 | Carbohydrate Polymers | 2015 | 9 Pages |
Abstract
The ileal brake mechanism which induces a potentially beneficial slower gastric emptying rate and increased satiety is triggered by macronutrients including glucose from glycemic carbohydrates. For optimization of this diet-induced health benefit, there is the need for a way to determine the location of glucose deposition in the small intestine. Labeled 2-deoxyglucose (2-DG) can be used to trace the location of glucose absorption due to its accumulative property in the small intestine enterocytes. However, because pure glucose, or 2-DG, is directly absorbed in the proximal small intestine, we designed 2-DG containing maltooligosaccharides (2-DG-MOs) that can be used with a mild α-glucosidase inhibitor to attain an analytical method for determining location-specific delivery of glucose and its physiological effect.
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Authors
Byung-Hoo Lee, Dong-Wan Koh, Paul R. Territo, Cheon-Seok Park, Bruce R. Hamaker, Sang-Ho Yoo,