Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7788062 | Carbohydrate Polymers | 2015 | 9 Pages |
Abstract
A new chitosan-based tri-block conjugate, O-PEG-chitosan-N-cysteine was synthesized using microwave irradiation. For synthesis of this derivative, chitosan was modified to a PEG-chitosan conjugate followed by PEG-chitosan-cysteine using 6-O PEGylation and 2-N-thiolation, respectively. The synthesized derivative was characterized using various analytical techniques such as FT-IR and 1H NMR spectroscopy. The conjugate was also analyzed for its biochemical, biodegradation and mucoadhesive properties. The modified chitosan conjugate exhibited improved mucoadhesion behavior (14.0Â h) with greater biodegradation compared to the parent polymer (6.3Â h). The in silico modeling corroborated with the in vitro study demonstrating a stable complex between mucin and O-PEG-chitosan-N-cysteine conjugate (ÎEÂ =Â â60.100Â kcal/mol) compared to mucin and chitosan conjugate. The synthesis proposed herein, involves the use of microwave irradiation which causes a substantial reduction in the reaction time (approximately 2.30Â h) compared to conventional method (35Â h).
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Authors
Ravindra V. Badhe, Rabindra K. Nanda, Dharmesh R. Chejara, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Viness Pillay,