Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7789380 | Carbohydrate Polymers | 2015 | 31 Pages |
Abstract
The rhizomes of Smilax glabra have been used as both food and folk medicine in many countries for a long time. However, little research has been reported on polysaccharides of S. glabra. In the present study, two polysaccharide fractions, SGP-1 and SGP-2, were isolated from the rhizomes of S. glabra with the number average molecular weights of 1.72 Ã 102 kDa and 1.31 Ã 102 kDa, and the weight average molecular weights of 1.31 Ã 105 kDa and 1.18 Ã 105 kDa, respectively, and their mainly monosaccharide compositions were both galactose and rhamnose (2.5:1). Both SGP-1 and SGP-2 significantly suppressed the release of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) from LPS-induced RAW 264.7 cells, as well as the mRNA expression of inducible nitric oxide synthase (iNOS), TNF-α and IL-6. Additionally, SGP-1 and SGP-2 repressed the extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK). These findings strongly suggested polysaccharides were also the anti-inflammatory active ingredient for S. glabra, and the potential of SGP-1 and SGP-2 as the anti-inflammatory agents.
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Authors
Lu Chuan-li, Zhu Wei, Wang Min, Hu Meng-mei, Chen Wen-long, Xu Xiao-jie, Lu Chuan-jian,