| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7790159 | Carbohydrate Polymers | 2015 | 7 Pages |
Abstract
New pectin derivative (Pec-MA) was obtained in specific reaction conditions. The presence of maleoyl groups in Pec-MA structure was confirmed by 1H NMR and FTIR spectroscopy. The substitution degree of Pec-MA (DSÂ =Â 24%) was determined by 1H NMR. The properties of Pec-MA were investigated through WAXS, TGA/DTG, SEM and zeta potential techniques. The Pec-MA presented amorphous characteristics and higher-thermal stability compared to raw pectin (Pec). In addition, considerable morphological differences between Pec-MA and Pec were observed by SEM. The cytotoxic effect on the Caco-2 cells showed that the Pec-MA significantly inhibited the growth of colon cancer cells whereas the Pec-MA does not show any cytotoxic effect on the VERO healthy cells. This result opens new perspectives for the manufacture of biomaterials based on Pec with anti-tumor properties.
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Authors
Elizângela A.M.S. Almeida, Suelen P. Facchi, Alessandro F. Martins, Samara Nocchi, Ivânia T.A. Schuquel, Celso V. Nakamura, Adley F. Rubira, Edvani C. Muniz,