Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7790449 | Carbohydrate Polymers | 2014 | 30 Pages |
Abstract
MDG-1, a water-soluble polysaccharide extracted from Ophiopogon japonicus, has potent hypoglycemic and weight control effects. We investigated the impact of MDG-1 on body weight, indirect calorimetry, body composition, plasma biochemical indices and obesity-related mitochondrial activity in diet-induced obese mice. Obese C57BL/6 mice induced by a high fat diet were given either vehicle or vehicle plus MDG-1 at 300Â mg per body weight for 16-weeks. MDG-1 could evoked weight loss and reduce adipose tissue mass (by up to â¼50%) in the obese animals by increasing oxygen consumption and energy expenditure without inhibiting appetite or increasing physical activity. In addition, MDG-1 could ameliorate plasma lipid profiles, decrease leptin secretion, attenuate hepatic lipid accumulation and increased the expressions of genes related to lipid and energy metabolism in the liver. MDG-1 is a promising candidate drug to treat obesity-related metabolic diseases.
Keywords
SOD2ERRαPDK4Ophiopogon japonicusPDKMCADRERCPT-1T2DMTFAMNRF-1PGC-1αSOD1qPCRLDL-CHFDPDCType 2 diabetes mellitusHigh fat dietdiet induced obesityMedium-chain acyl-CoA dehydrogenaseSODmanganese superoxide dismutaseSuperoxide dismutasecopper zinc superoxide dismutaseAnti-obesitymitochondrial transcription factor AMitochondrial functionRespiratory exchange ratioEnergy expenditureHematoxylin and Eosinquantitative real-time polymerase chain reactionperoxisome proliferator-activated receptor-γ coactivatorpyruvate dehydrogenase complexPyruvate dehydrogenase kinase 4Polysaccharidelow density lipoprotein cholesterolestrogen-related receptor α
Related Topics
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Authors
Yuan Wang, Yunyun Zhu, Kefeng Ruan, Hai Wei, Yi Feng,