| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7790585 | Carbohydrate Polymers | 2014 | 9 Pages |
Abstract
This study reports on the synthesis, characterization and in vitro testing of a new liver specific carrier based on linear cationic diblock glycopolymer composed of galactosyl ureaethyl methacrylate (GAMA) and the primary amine-containing dimethylamino ethyl methacrylate (DMAEMA). Delivery experiments proved that the poly(galactosyl ureaethyl methacrylate -b-dimethylamino ethyl methacrylate) diblock copolymer (pGa4D47), internalized in a receptor-mediated manner, exhibited a much faster nuclear transportation than ODNs carried by pDMAEMA homopolymer or glycopolymer bearing glucose moieties.
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Authors
M.C. Munisso, S. Obika, T. Yamaoka,