Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7790607 | Carbohydrate Polymers | 2014 | 9 Pages |
Abstract
Natural polymer-based hydrogels are of interest to health care professionals as wound dressings owing to their ability to absorb exudates and provide hydration for healing. The aims of this study were to develop and characterize bacterial cellulose/acrylic acid (BC/AA) hydrogels synthesized by electron beam irradiation and investigate its wound healing potential in an animal model. The BC/AA hydrogels were characterized by SEM, tensile strength, water absorptivity, and water vapor transmission rate (WVTR). The cytotoxicity of the hydrogels was investigated in L929 cells. Skin irritation and wound healing properties were evaluated in Sprague-Dawley rats. BC/AA hydrogels had a macroporous network structure, high swelling ratio (4000-6000% at 24Â h), and high WVTR (2175-2280Â g/m2/day). The hydrogels were non-toxic in the cell viability assay. In vivo experiments indicated that hydrogels promoted faster wound-healing, enhanced epithelialization, and accelerated fibroblast proliferation compared to that in the control group. These results suggest that BC/AA hydrogels are promising materials for burn dressings.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Najwa Mohamad, Mohd Cairul Iqbal Mohd Amin, Manisha Pandey, Naveed Ahmad, Nor Fadilah Rajab,