Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers

- Core-sheath electrospun nanofibers with naproxen and naproxen-loaded liposomes in the core were produced.
- Naproxen-loaded hybrid and core-sheath nanofibers were also prepared for comparison.
- Naproxen formed hydrogen bonds with the polymer molecules and dispersed homogenously in the polymer matrixes.
- Hybrid and core-sheath nanofibers released the naproxen in 24 h.
- Liposome-loaded core-sheath nanofibers showed a specific drug release behavior with a burst release within 8 h and then a sustained drug release as long as 12 days.