Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7793442 | Carbohydrate Polymers | 2014 | 7 Pages |
Abstract
Shape-memory resorbable materials were obtained by extrusion-cooking of potato starch with 20% glycerol under usual conditions. They presented an efficient shape-memory with a high recovery ratio (Rr > 90%). Their recovery could be triggered at 37 °C in water. After water immersion at 37 °C, the modulus decreased from 1 GPa to 2.4 MPa and remained almost constant over 21 days. Gamma-ray sterilization did not have a dramatic impact on their mechanical properties, despite a large decrease of molecular mass analyzed by asymmetrical flow field-flow fractionation coupled with multi-angle laser light scattering (AFFFF-MALLS). Samples implanted in a rat model exhibited normal tissue integration with a low inflammatory response. Thus, as previously investigated in the case of shape-memory synthetic polymers, natural starch, without chemical grafting, can now be considered for manufacturing innovative biodegradable devices for less-invasive surgery.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
A. Beilvert, F. Chaubet, L. Chaunier, S. Guilois, G. Pavon-Djavid, D. Letourneur, A. Meddahi-Pellé, D. Lourdin,