Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7794249 | Carbohydrate Research | 2015 | 9 Pages |
Abstract
- Metamorphosis of the structure of heparin over the years.
- History of identification and chemical synthesis of major and minor sequences, among which the specific pentasaccharidic sequence of the active site for antithrombin.
- Peculiar conformational properties of iduronic acid-containing heparin sequences and proof of their role in protein binding and eliciting biological activities.
Keywords
TSDHeparin oligosaccharidesFGF1IdoAGlcAFGFsGlcNLMWHFGFRFGF2GAGd-glucosamineantithrombind-Glucuronic acidl-Iduronic acidConformationsFibroblast Growth FactorsFibroblast growth factor-1fibroblast growth factor-2Low-molecular-weight heparinslow-molecular-weight heparinProtein bindingGlycosaminoglycanfibroblast growth factor receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Benito Casu, Annamaria Naggi, Giangiacomo Torri,