Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy

- Synthesis of a matrix of sulfation-programmed GlcN-IdoA disaccharides.
- Demonstrates effective synthesis using various GlcN donors and Ido acceptor.
- Four homogeneous sulfation-varied heparin disaccharides used to obtain Raman and Raman ROA data.
- Spectra provide indicative comparisons of signature sulfation bands for differing sulfation levels.
- Data are used to provide comparisons/differences to native heparin spectra.