Synthesis of new pyrimidine-fused derivatives as potent and selective antidiabetic α-glucosidase inhibitors

- Synthesis of new pyrimidine-fused heterocycles (PFH) as potent and selective α-Gls inhibitors.
- The PFH ring plays an important role in the inhibitory activity of synthetic ligands.
- The rigidity/flexibility of hinge-like connection is key in the inhibitory activity.
- The synthesized ligands weakly inhibit the activity of pancreatic α-Amy.