| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7795864 | European Journal of Medicinal Chemistry | 2018 | 28 Pages |
Abstract
Three series of novel sulfonamides incorporating substituted isatin moieties linked to benzenesulfonamide through hydrazide linkers were synthesized and evaluated for their inhibitory activity against a panel of carbonic anhydrase isoforms hCA I, II, IX and XII. 10b emerged as a single-digit nanomolar hCA IX and XII inhibitor (8.9 and 9.2â¯nM, respectively). Molecular docking studies were carried out for 10b within the hCA II, IX and XII active sites.265
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Authors
Mahmoud F. Abo-Ashour, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Silvia Bua, Sahar M. Abou-Seri, Claudiu T. Supuran,