| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7795969 | European Journal of Medicinal Chemistry | 2018 | 25 Pages |
Abstract
A series of dihydropyrimidinone derivatives bearing various heteroaryl moieties was designed, synthesized and evaluated for anticancer activity. Compound 19 possessed the most significant activity against NCI-H460, SK-MEL-5 and HL-60 (TB) cell lines. It proved to have dual inhibitory effect against VEGFR-2 and m TOR. Cell cycle analysis of A549â¯cells showed cell cycle arrest at G2/M phase and pro-apoptotic activity.177
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Authors
Amany S. Mostafa, Khalid B. Selim,