Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors

Article ID	Journal	Published Year	Pages	File Type
7795999	European Journal of Medicinal Chemistry	2018	36 Pages	PDF

Keywords

SAR βME Eg5 KSP ITC PDB RPM HEPES 1,3,4-Thiadiazole 2-(N-morpholino)ethanesulfonic acid 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid DMSO piperazine-N,N′-bis(2-ethanesulfonic acid)β-mercaptoethanol Antimitotic drugs rounds per minute Dimethylsulfoxide Structure-activity relationship Microtubule Rational drug design lactate dehydrogenase LDH Pipes MeS asymmetric unit Kinesin spindle protein Protein Data Bank polyethyleneglycol PEG pyruvate kinase Isothermal titration calorimetry

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors

Authors

Sandeep K. Talapatra, Chuin Lean Tham, Paolo Guglielmi, Roberto Cirilli, Balakumar Chandrasekaran, Rajshekhar Karpoormath, Simone Carradori, Frank Kozielski,