Article ID Journal Published Year Pages File Type
7796070 European Journal of Medicinal Chemistry 2018 37 Pages PDF
Abstract
A series of dual binding site BuChE inhibitors were designed and synthesized based on 2,3,4,9-tetrahydro-1H-carbazole attached benzyl pyridine moieties. The most potent BuChE inhibitor was compound 6i (IC50 = 0.088 μM). In addition, compound 6i demonstrated neuroprotective and β-secretase inhibition activities.223
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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