Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7796070 | European Journal of Medicinal Chemistry | 2018 | 37 Pages |
Abstract
A series of dual binding site BuChE inhibitors were designed and synthesized based on 2,3,4,9-tetrahydro-1H-carbazole attached benzyl pyridine moieties. The most potent BuChE inhibitor was compound 6i (IC50â¯=â¯0.088â¯Î¼M). In addition, compound 6i demonstrated neuroprotective and β-secretase inhibition activities.223
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Authors
Roshanak Ghobadian, Mohammad Mahdavi, Hamid Nadri, Alireza Moradi, Najmeh Edraki, Tahmineh Akbarzadeh, Mohammad Sharifzadeh, Syed Nasir Abbas Bukhari, Mohsen Amini,