Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7796160 | European Journal of Medicinal Chemistry | 2018 | 12 Pages |
Abstract
We synthesized two mono-functional platinum complexes, which target the mitochondria and exhibit high cytotoxicity, including in cisplatin-resistant cells. Mon-Pt-2 induced a significant ROS release and ER stress response mediated by mitochondrial dysfunction, ultimately resulting in simultaneous apoptosis and pro-autophagy in A549â¯cells. Importantly, compared to cisplatin, Mon-Pt-2 exhibits lower toxicity and better anticancer activity in a murine tumor model.320
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Authors
Feng-Yang Wang, Xiao-Ming Tang, Xia Wang, Ke-Bin Huang, Hai-Wen Feng, Zhen-Feng Chen, You-Nian Liu, Hong Liang,