| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7796256 | European Journal of Medicinal Chemistry | 2018 | 13 Pages |
Abstract
Two new Cu(II) dipeptide complexes based on HPBM were synthesized and characterized. The complexes were found to bind to CT DNA by an intercalative mode. The complexes exhibited good antimicrobial and cytotoxic activities. Moreover, the possible anticancer mechanism of the complexes was explored by determining the cells morphological changes, intracellular reactive oxygen species (ROS) levels, location in mitochondria, mitochondrial membrane potentials and the expression of Bcl-2 family proteins.233
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Authors
Yong-Yu Qi, Qian Gan, Ya-Xian Liu, Ya-Hong Xiong, Zong-Wan Mao, Xue-Yi Le,