Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses

Article ID	Journal	Published Year	Pages	File Type
7796274	European Journal of Medicinal Chemistry	2018	46 Pages	PDF

Keywords

IC50 GLN PBS THR MDCK EC50 TFA BOC CC50 Peramivir PDB TPG THF 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate GOC ESI Acylguanidine tert-butoxycarbonyl (Boc)2O CPE HBTU LD50 DIEA DMSO Arginine Influenza Cytopathic effect Arg Oseltamivir Trifluoroacetic acid SER Tetrahydrofuran threonine Dimethylsulfoxide Zanamivir val Serine Phosphate buffered saline Neuraminidase inhibitor MUNANA median lethal dose PRO neuraminidase half maximal inhibitory concentration half maximal effective concentration hemagglutinin Valine Protein Data Bank Proline Madin–Darby Canine Kidney glutamine electrospray ionization

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses

Authors

Peng-Hao Hsu, Din-Chi Chiu, Kuan-Lin Wu, Pei-Shan Lee, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Keng-Chang Tsai, Ting-Jen Cheng, Jim-Min Fang,