Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position

Article ID	Journal	Published Year	Pages	File Type
7796275	European Journal of Medicinal Chemistry	2018	70 Pages	PDF

Keywords

DMF 5-FU DSB EDCI SDS CPT tert-butyloxycarbonyl BOC MTS γ-H2AX TFA SAC 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt DMSO N,N-dimethylformamide EDTA Ethylenediaminetetraacetic acid Trifluoroacetic acid spindle assembly checkpoint triethylamine tubulin Thieno[2,3-d]pyrimidine Room temperature dimethyl sulphoxide Dithiocarbamate sodium dodecyl sulfate Cytotoxicity Target identification DNA double-strand break 5-fluorouracil Probe Propidium iodide TEA camptothecin

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position

Authors

Chao-Rui Yang, Bin Peng, Sheng-Li Cao, Ting-Ting Ren, Wei Jiang, Fu-Cheng Wang, You-Shan Li, Guo Wang, Zheng Li, Shibin Xu, Ji Liao, Hailong Wang, Jing Li, Xingzhi Xu,