New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV

Article ID	Journal	Published Year	Pages	File Type
7796327	European Journal of Medicinal Chemistry	2018	24 Pages	PDF

Keywords

HERG Simocyclinone D8 Topoisomerase IV FBDD gyrA QRDR gyrB PARC DSF MIC PDB FBS SAR IC50 MDR nuclear magnetic resonance DNA Adenosine Triphosphate ATP deoxyribonucleic acid Pare NMR Potency Minimum inhibitory concentration Structure activity relationship Differential scanning fluorimetry Binding sites Drug resistance Protein Data Bank Multi drug resistant Fragment-based drug discovery

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV

Authors

Syed Lal Badshah, Asad Ullah,